VDR is known as a receptor that plays a role in phosphate and calcium supplement absorption through the gut. It can be found in a variety of cells within the body. For example, it is indicated in kidneys, intestines, bones, epithelial cells, and skin.

To be able to understand VDR’s role in bone development, researchers viewed how cuboid density is normally correlated with VDR receptor alleles in individuals. They located that a innate variant for the VDR was associated with decreased vitamin D amounts. This obtaining supports the notion the VDR gene plays a position in bone development.

Research workers have also examined the effect of pharmacologic doses of calciferol derivatives on the process of VDR. These studies showed that the pharmacologic dose of 10-7 M of 1, 25-dihydroxyvitamin continue reading this D3 decreased VDR mRNA phrase by 50% in HL-60 cells after 24 hours.

Research using people primary glioblastoma cell lines have shown that the VDR protein exists in a variety of the immune system cell types, including a subsection, subdivision, subgroup, subcategory, subclass of glia. However , in the majority of instances, the healthy proteins seems to lack any kind of distinct VDR-like features.

In addition , the presence of VDR is also believed to play a role in the maintenance of mineral balance. The VDR/RXR intricate relays the signal through hydrogen-deuterium exchange.

Functional studies have suggested that the protein may contain a number of fields. In particular, the ligand-binding website, which is located between amino acids 317 and 395, may be essential for heterodimerization.